Clinical Studies

SPLENDA^® Brand Sweetener has undergone rigorous clinical testing

Rigorous testing of the safety of sucralose have been conducted. Click to view summaries of published clinical studies demonstrating the lack of effect of sucralose on glycemic control and dental caries.

• Glycemic effect of a single high oral dose of the novel sweetener sucralose in patients with diabetes.

  Mezitis NHE, Maggio CA, Koch P, Quddoos A, Allison DB, Pi-Sunyer FX. Diab Care. 1996;19(9):1004-1005.

• Dental considerations in sucralose use.

  Mandel ID, Grotz VL. J Clin Dentistry. 2002;13(3):116-118.

• Lack of effect of sucralose on glucose homeostasis in subjects with type 2 diabetes.

  Grotz VL, Henry RR, McGill JB, et al. J Am Diet Assn. 2003;103(12):1607-1612.